Critical role of protein kinase C epsilon for lipopolysaccharide-induced IL-12 synthesis in monocyte-derived dendritic cells.

@article{Aksoy2002CriticalRO,
  title={Critical role of protein kinase C epsilon for lipopolysaccharide-induced IL-12 synthesis in monocyte-derived dendritic cells.},
  author={Ezra Aksoy and Zoulikha Amraoui and Stanislas Goriely and Michel Goldman and F. Th. C. Willems},
  journal={European journal of immunology},
  year={2002},
  volume={32 11},
  pages={
          3040-9
        }
}
In the present study we have investigated the potential involvement of protein kinase C (PKC) in the maturation of human dendritic cells (DC) by bacterial lipopolysaccharide (LPS). LPS stimulation of DC derived from human monocytes resulted in PKC phosphorylation. Inhibition of PKC activation using bisindolylmaleimide (Bis), a pan-PKC inhibitor, was associated with a dose-dependent decrease of LPS-induced IL-12 production. In contrast, up-regulation of MHC class II, CD80 and CD86 was not… CONTINUE READING

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