Critical role of plasminogen activator inhibitor-1 in cholestatic liver injury and fibrosis.

@article{Bergheim2006CriticalRO,
  title={Critical role of plasminogen activator inhibitor-1 in cholestatic liver injury and fibrosis.},
  author={Ina Bergheim and Luping Guo and Molly Anne Davis and Ilinca Duveau and Gavin E. Arteel},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2006},
  volume={316 2},
  pages={592-600}
}
Plasminogen activator inhibitor-1 (PAI-1) is an acute phase protein known to correlate with hepatic fibrosis. However, whether or not PAI-1 plays a causal role in this disease process had not been directly tested. Therefore, wild-type or PAI-1 knockout (PAI-1(-/-)) mice underwent bile duct ligation. Mice were sacrificed either 3 or 14 days after surgery for assessment of early (i.e., inflammation) and late (i.e., fibrosis) changes caused by bile duct ligation. Liver injury was determined by… CONTINUE READING
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