Critical role of peripheral sensory systems in mediating the neural effects of nicotine following its acute and repeated exposure.

@article{Kiyatkin2014CriticalRO,
  title={Critical role of peripheral sensory systems in mediating the neural effects of nicotine following its acute and repeated exposure.},
  author={Eugene A Kiyatkin},
  journal={Reviews in the neurosciences},
  year={2014},
  volume={25 2},
  pages={207-21}
}
It is well established that the reinforcing properties of nicotine (NIC) depend on its action on nicotinic acetylcholine receptors expressed by brain neurons. However, when administered systemically, NIC first phasically activates nicotinic receptors located on the afferents of sensory nerves at the sites of drug administration before reaching the brain and directly interacting with central neurons. While this peripheral action of NIC has been known for years, it is usually neglected in any… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 55 references

nicotine related to addiction

  • E. F. Domino
  • Eur. J. Pharmacol
  • 2001
Highly Influential
4 Excerpts

The effects of nicotine

  • P. B. Press. Clark, R. Kumar
  • 1983
Highly Influential
4 Excerpts

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