Critical role of monoubiquitination of histone H2AX protein in histone H2AX phosphorylation and DNA damage response.

@article{Wu2011CriticalRO,
  title={Critical role of monoubiquitination of histone H2AX protein in histone H2AX phosphorylation and DNA damage response.},
  author={Ching-Yuan Wu and Hong-Yo Kang and W Yang and Juan Anna Wu and Yun Seong Jeong and Jing Wang and Chia-Hsin Chan and Szu-Wei Lee and Xian Zhang and Betty Lamothe and A. M. de Campos and Bryant G. Darnay and Hui-Kuan Lin},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 35},
  pages={
          30806-15
        }
}
DNA damage response is an important surveillance mechanism used to maintain the integrity of the human genome in response to genotoxic stress. Histone variant H2AX is a critical sensor that undergoes phosphorylation at serine 139 upon genotoxic stress, which provides a docking site to recruit the mediator of DNA damage checkpoint protein 1 (MDC1) and DNA repair protein complex to sites of DNA breaks for DNA repair. Here, we show that monoubiquitination of H2AX is induced upon DNA double strand… CONTINUE READING
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Monoubiquitination of H2AX in DNA Damage

Bryant G. Darnay, Hui-Kuan Lin Campos, +9 authors Hong-Yo Kang
J. Biol. Chem. 286, • 2011