Critical role of monocyte chemoattractant protein-1 receptor CCR2 on monocytes in hypertension-induced vascular inflammation and remodeling.

@article{Ishibashi2004CriticalRO,
  title={Critical role of monocyte chemoattractant protein-1 receptor CCR2 on monocytes in hypertension-induced vascular inflammation and remodeling.},
  author={Minako Ishibashi and Ken-ichi Hiasa and Qingwei Zhao and Shujiro Inoue and Kisho Ohtani and Shiro Kitamoto and Miyuki Tsuchihashi and Takeshi Sugaya and Israel F. Charo and Shinobu Kura and Teruhisa Tsuzuki and T Ishibashi and Akira Takeshita and Kensuke Egashira},
  journal={Circulation research},
  year={2004},
  volume={94 9},
  pages={1203-10}
}
Activated monocytes are present in the arterial walls of hypertensive patients and animals. Monocyte chemoattractant protein-1 (MCP-1), which controls monocyte function through its receptor (CCR2), is implicated in hypertensive inflammatory changes in the arterial wall. The role of CCR2 expression on monocytes in hypertension-induced vascular remodeling, however, has not been addressed. We hypothesized that CCR2 on monocytes is critical in hypertension-induced vascular inflammation and… CONTINUE READING

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Hypertension and the pathogenesis of atherosclerosis: oxidative stress and the mediation of arterial inflammatory response: a new perspective. Hypertension

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