Critical role of micelles in pancreatic lipase activation revealed by small angle neutron scattering.

@article{Pignol2000CriticalRO,
  title={Critical role of micelles in pancreatic lipase activation revealed by small angle neutron scattering.},
  author={David Pignol and L F Ayvazian and Brigitte Kerfelec and Peter Timmins and Isabelle Crenon and Juan Carlos Hermoso and Juan C Fontecilla-Camps and Catherine Chapus},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 6},
  pages={4220-4}
}
In the duodenum, pancreatic lipase (PL) develops its activity on triglycerides by binding to the bile-emulsified oil droplets in the presence of its protein cofactor pancreatic colipase (PC). The neutron crystal structure of a PC-PL-micelle complex (Hermoso, J., Pignol, D., Penel, S., Roth, M., Chapus, C., and Fontecilla-Camps, J. C. (1997) EMBO J. 16, 5531-5536) has suggested that the stabilization of the enzyme in its active conformation and its adsorption to the emulsified oil droplets are… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-2 of 2 references

ILL Internal Report, 81GH29T, ILL Publishers, Grenoble, France

R. Ghosh
1981

Role of Micelles in Lipase Activation Revealed by SANS

A. Hofmann, D. M. Small
Annu. Rev. Med • 1967

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