Critical role of miR-125b in lipogenesis by targeting stearoyl-CoA desaturase-1 (SCD-1).

  title={Critical role of miR-125b in lipogenesis by targeting stearoyl-CoA desaturase-1 (SCD-1).},
  author={X. Cheng and Qian-yun Xi and S Wei and D. Wu and Rui-Song Ye and T Chen and Qi-En Qi and Qingyan Jiang and S.-B. Wang and L-N Wang and X-T Zhu and Y-L Zhang},
  journal={Journal of animal science},
  volume={94 1},
Alteration of gene expression tightly regulates lipogenesis. Stearoyl-CoA desaturase-1 (SCD-1), a key enzyme in lipogenesis, catalyzes the conversion of SFA to MUFA, and inhibition of its activity impairs lipid synthesis. As posttranscriptional regulators, microRNAs are involved in many pathways of lipid metabolism; however, their effect on SCD-1 has not been reported. In this study, miR-125b was identified as a potential regulator of SCD-1 using bioinformatics analysis. Here, we validated SCD… 

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  • C. PatonJ. Ntambi
  • Biology
    American journal of physiology. Endocrinology and metabolism
  • 2009
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