Critical role of magnesium ions in DNA polymerase beta's closing and active site assembly.

Abstract

To dissect the effects of the nucleotide-binding and catalytic metal ions on DNA polymerase mechanisms for DNA repair and synthesis, aside from the chemical reaction, we investigate their roles in the conformational transitions between closed and open states and assembly/disassembly of the active site of polymerase beta/DNA complexes before and after the… (More)

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@article{Yang2004CriticalRO, title={Critical role of magnesium ions in DNA polymerase beta's closing and active site assembly.}, author={Linjing Yang and Karunesh Arora and William A. Beard and Samuel H. Wilson and Tamar Schlick}, journal={Journal of the American Chemical Society}, year={2004}, volume={126 27}, pages={8441-53} }