Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair

@inproceedings{Sone2014CriticalRO,
  title={Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair},
  author={Kenbun Sone and Lianhua Piao and Makoto Nakakido and Koji Ueda and Thomas Jenuwein and Yusuke Nakamura and Ryuji Hamamoto},
  booktitle={Nature communications},
  year={2014}
}
The presence of phosphorylated histone H2AX (γ-H2AX) is associated with the local activation of DNA-damage repair pathways. Although γ-H2AX deregulation in cancer has previously been reported, the molecular mechanism involved and its relationship with other histone modifications remain largely unknown. Here we find that the histone methyltransferase SUV39H2 methylates histone H2AX on lysine 134. When H2AX was mutated to abolish K134 methylation, the level of γ-H2AX became significantly reduced… CONTINUE READING

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