Critical role of interleukin-17/interleukin-17 receptor axis in mediating Con A-induced hepatitis.

@article{Yan2012CriticalRO,
  title={Critical role of interleukin-17/interleukin-17 receptor axis in mediating Con A-induced hepatitis.},
  author={Shu Yan and Luman Wang and Nan Liu and Ying Wang and Yiwei Chu},
  journal={Immunology and cell biology},
  year={2012},
  volume={90 4},
  pages={
          421-8
        }
}
Concanavalin A (Con A)-induced hepatitis is thought to be a T-cell-mediated disease with active destruction of liver cells. Interleukin (IL)-17 is a cytokine produced principally by CD4(+) T cells. However, whether IL-17/IL-17 receptor (IL-17/IL-17R)-mediated responses are involved in T-cell-mediated Con A-induced liver injury remains unclear. In this study, we found that IL-17 expression was highly elevated in liver tissues during Con A-induced hepatitis. The increased levels of IL-17 were… CONTINUE READING
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