Critical role of interferon regulatory factor-1 in murine liver transplant ischemia reperfusion injury.

@article{Ueki2010CriticalRO,
  title={Critical role of interferon regulatory factor-1 in murine liver transplant ischemia reperfusion injury.},
  author={Shinya Ueki and Rajeev Dhupar and Jon Cardinal and Allan Tsung and Junichi Yoshida and Kikumi S. Ozaki and John Robert Klune and Noriko Murase and David A. Geller},
  journal={Hepatology},
  year={2010},
  volume={51 5},
  pages={1692-701}
}
Interferon regulatory factor-1 (IRF-1) is a transcription factor that regulates gene expression during immunity. We hypothesized that IRF-1 plays a pivotal role in liver transplant (LTx) ischemia/reperfusion (I/R) injury. Mouse orthotopic LTx was conducted after 24 hours cold storage in University of Wisconsin (UW) solution in wildtype (WT) C57BL/6 and IRF-1 knockout (KO) mice. IRF-1 deficiency in liver grafts, but not in recipients, resulted in significant reduction of hepatocyte apoptosis and… CONTINUE READING
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