Critical role of hypoxia and A2A adenosine receptors in liver tissue-protecting physiological anti-inflammatory pathway.

@article{Choukr2008CriticalRO,
  title={Critical role of hypoxia and A2A adenosine receptors in liver tissue-protecting physiological anti-inflammatory pathway.},
  author={Alexander Chouk{\'e}r and Manfred Thiel and Dmitriy E Lukashev and Jerrold M Ward and Ines Kaufmann and Sergey G. Apasov and Michail Sitkovsky and Akio Ohta},
  journal={Molecular medicine},
  year={2008},
  volume={14 3-4},
  pages={
          116-23
        }
}
Whole body exposure of wild type control littermates and A2A adenosine receptor (A2AR) gene deleted mice to low oxygen containing inspired gas mixture allowed the investigation of the mechanism that controls inflammatory liver damage and protects the liver using a mouse model of T cell-mediated viral and autoimmune hepatitis. We tested the hypothesis that the inflammatory tissue damage-associated hypoxia and extracellular adenosine --> A2AR signaling plays an important role in the physiological… CONTINUE READING

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