Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T cell differentiation

@article{Li2014CriticalRO,
  title={Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T cell differentiation},
  author={Qingtian Li and Jia Zou and Mingjun Wang and Xilai Ding and I. Chepelev and Xikun Zhou and Wei Zhao and Gang Wei and J. Cui and K. Zhao and H. Wang and R. Wang},
  journal={Nature communications},
  year={2014},
  volume={5},
  pages={5780 - 5780}
}
Epigenetic factors have been implicated in the regulation of CD4+ T cell differentiation. Jmjd3 plays a role in many biological processes, but its in vivo function in T cell differentiation remains unknown. Here, we report that Jmjd3 ablation promotes CD4+ T cell differentiation into Th2 and Th17 cells in the small intestine and colon, and inhibits T cell differentiation into Th1 cells under different cytokine-polarizing conditions and in a Th1-dependent colitis model. Jmjd3 deficiency also… Expand
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