Critical role of factor XIII in the initial stages of carbon tetrachloride-induced adult liver remodeling.

@article{Tsujimoto2011CriticalRO,
  title={Critical role of factor XIII in the initial stages of carbon tetrachloride-induced adult liver remodeling.},
  author={Ikuko Tsujimoto and Kei Moriya and Keiko Sakai and Gerhard Dickneite and Takao Sakai},
  journal={The American journal of pathology},
  year={2011},
  volume={179 6},
  pages={3011-9}
}
The transglutaminase-mediated, covalent cross-linking of proteins is an essential step in tissue remodeling after injury. This process provides tissues with extra rigidity and resistance against proteolytic degradation. Plasma coagulation factor XIII (FXIII) is a transglutaminase that promotes cross-linking of the extracellular matrix (ECM) components fibrin and fibronectin to form a provisional matrix in response to tissue damage. However, the functional requirement for this FXIII-mediated… CONTINUE READING

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Advances of Coagulation Factor XIII

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New developments in the area of factor XIII.

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