Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms.

@article{Chou2003CriticalRO,
  title={Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms.},
  author={Thomas C. Chou and Thomas E Scammell and Joshua J. Gooley and Stephanie E. Gaus and Clifford B. Saper and Jun Lu},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 33},
  pages={10691-702}
}
The suprachiasmatic nucleus (SCN) contains the brain's circadian pacemaker, but mechanisms by which it controls circadian rhythms of sleep and related behaviors are poorly understood. Previous anatomic evidence has implicated the dorsomedial hypothalamic nucleus (DMH) in circadian control of sleep, but this hypothesis remains untested. We now show that excitotoxic lesions of the DMH reduce circadian rhythms of wakefulness, feeding, locomotor activity, and serum corticosteroid levels by 78-89… CONTINUE READING
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