Critical role of costimulation in the activation of naive antigen-specific TCR transgenic CD8+ T cells in vitro.

@article{Chai1999CriticalRO,
  title={Critical role of costimulation in the activation of naive antigen-specific TCR transgenic CD8+ T cells in vitro.},
  author={J G Chai and Silvia Vendetti and Istvan Bartok and Diana Schoendorf and Katalin Tak{\'a}cs and Jan N Elliott and R. Lechler and Julian P. Dyson},
  journal={Journal of immunology},
  year={1999},
  volume={163 3},
  pages={1298-305}
}
The influence of costimulation on the activation of naive CD8+ T cells and thymocytes was studied in vitro using H-Y-specific TCR-transgenic mice and H-Y antigenic peptide. Using a variety of physiological APC types, the activation of naive CD8+ T cells depended strictly on costimulation, which could not be substituted by high epitope density. T cell activation is known to be regulated by the interactions between CD86/CD80 and CD28/CD152, although it remains unclear whether the B7 isoforms have… CONTINUE READING

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