Critical role of chromium (Cr)-DNA interactions in the formation of Cr-induced polymerase arresting lesions.

@article{OBrien2002CriticalRO,
  title={Critical role of chromium (Cr)-DNA interactions in the formation of Cr-induced polymerase arresting lesions.},
  author={Travis J O'Brien and H. George Mandel and Daryl E. Pritchard and Steven R. Patierno},
  journal={Biochemistry},
  year={2002},
  volume={41 41},
  pages={12529-37}
}
The genotoxicity associated with the metabolic reduction of hexavalent chromium [Cr(VI)] is complex and can impede DNA polymerase-mediated replication in vitro. The exact biochemical nature of Cr-induced polymerase arresting lesions (PALs) is not understood, but is believed to involve the formation of Cr-DNA interstrand cross-links (ICLs). The aim of this investigation was to determine the dependence of direct Cr-DNA interactions on the development of PALs in DNA treated with trivalent Cr [Cr… CONTINUE READING