Critical role of cAMP-response element-binding protein for angiotensin II-induced hypertrophy of vascular smooth muscle cells.

@article{Funakoshi2002CriticalRO,
  title={Critical role of cAMP-response element-binding protein for angiotensin II-induced hypertrophy of vascular smooth muscle cells.},
  author={Yuko Funakoshi and Toshihiro Ichiki and Kotaro Takeda and Tomotake Tokuno and Naoko Iino and Akira Takeshita},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 21},
  pages={
          18710-7
        }
}
We reported previously an important role of cyclic AMP-response element (CRE) for the induction of interleukin-6 gene expression by angiotensin II (AngII). We examined signaling pathways that are responsible for AngII-induced phosphorylation of CRE-binding protein (CREB) at serine 133 that is a critical marker for the activation in rat vascular smooth muscle cells (VSMC). AngII time dependently induced phosphorylation of CREB with a peak at 5 min. The AngII-induced phosphorylation of CREB was… CONTINUE READING

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