Critical role of androgen receptor in the postnatal period in male sexual behavior in rats.

@article{Yamada2015CriticalRO,
  title={Critical role of androgen receptor in the postnatal period in male sexual behavior in rats.},
  author={Shunji Yamada and Miku Ohoya and Keiko Takanami and Ken Matsuda and Mitsuhiro Kawata},
  journal={Neuroscience letters},
  year={2015},
  volume={609},
  pages={189-93}
}
Gonadal hormones have a developmental role in organization of the nervous system that regulates sexually dimorphic behavior. It is well known that androgen secreted from testes in the perinatal period is converted to estrogen by aromatase in rodent brain, and that estrogen and its receptor play a pivotal role in masculinization of brain structure and function. Treatment with flutamide, an androgen receptor (AR) antagonist, during the perinatal period inhibits development of malespecific brain… CONTINUE READING
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