Critical role of allyl groups and disulfide chain in induction of Pi class glutathione transferase in mouse tissues in vivo by diallyl disulfide, a naturally occurring chemopreventive agent in garlic.

Abstract

We have shown previously that the chemoprotective activity of diallyl disulfide (DADS), a naturally occurring anticancer agent in garlic, against benzo[a]pyrene (BP)-induced forestomach carcinogenesis in mice correlates strongly with its inductive effects on the expression of Pi class glutathione (GSH) transferase mGSTP1-1. The present structure-activity… (More)

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@article{Bose2002CriticalRO, title={Critical role of allyl groups and disulfide chain in induction of Pi class glutathione transferase in mouse tissues in vivo by diallyl disulfide, a naturally occurring chemopreventive agent in garlic.}, author={Chhanda Bose and Jianxia Guo and Ludwika Zimniak and Sanjay K. Srivastava and Sharda P. Singh and Piotr Zimniak and Shivendra Vikram Singh}, journal={Carcinogenesis}, year={2002}, volume={23 10}, pages={1661-5} }