Critical role of Rho in cell transformation by oncogenic Ras.

Abstract

We demonstrate that Rho, a regulator of cytoskeletal actin, is necessary for Ras transformation. A dominant inhibitory Rho gene (RhoBN19) specifically suppressed Rat1 cell focus formation induced by oncogenic Ras but not by Raf. An activated Rho gene (RhoBV14) lacked focus formation activity but augmented the focus formation activity of both oncogenes… (More)

Topics

Cite this paper

@article{Prendergast1995CriticalRO, title={Critical role of Rho in cell transformation by oncogenic Ras.}, author={George C. Prendergast and Roya Khosravi-Far and Patricia Solski and Holly L. Kurzawa and Peter F. Lebowitz and Channing J Der}, journal={Oncogene}, year={1995}, volume={10 12}, pages={2289-96} }