Critical role of Pcid2 in B cell survival through the regulation of MAD2 expression.

Abstract

The mitotic checkpoint is essential for maintaining genomic stability in differentiating B cells undergoing genetic alterations of the Ig gene. In this study, using real-time RT-PCR and in situ RNA hybridization, we demonstrated that MAD2 mRNA export is selectively regulated by Pcid2/Thp1. Pcid2 small interfering RNA induced a cell-cycle abnormality with… (More)
DOI: 10.4049/jimmunol.1002026

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