Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury.

@article{Zhang2007CriticalRO,
  title={Critical role of PTEN in the coupling between PI3K/Akt and JNK1/2 signaling in ischemic brain injury.},
  author={Quanguang Zhang and Dong-na Wu and Dong Han and Guang-yi Zhang},
  journal={FEBS letters},
  year={2007},
  volume={581 3},
  pages={495-505}
}
JNK pathway is an important pro-apoptotic kinase cascade mediating cell death in response to a variety of extracellular stimuli including excitotoxicity, which results in selective and delayed neuronal death in the hippocampal CA1. On the contrary, activation of the protein kinase Akt, which is controlled by the opposing actions of PI3K and PTEN, contributes to enhanced resistance to apoptosis through multiple mechanisms. We here demonstrate that the temporal pattern of Akt activation reversely… CONTINUE READING
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