Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells.

@article{Kloo2011CriticalRO,
  title={Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells.},
  author={Bernhard Kloo and Daniel M Nagel and Matthias Pfeifer and Michael J Grau and Michael D{\"u}wel and Michelle Vincendeau and Bernd Doerken and Peter Lenz and Georg Lenz and Daniel Krappmann},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 1},
  pages={272-7}
}
The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) represents a very aggressive human lymphoma entity. Constitutive NF-κB activation caused by chronic active B-cell receptor (BCR) signaling is common feature of many ABC DLBCL cells; however, the pathways linking BCR signaling to the NF-κB prosurvival network are largely unknown. Here we report that constitutive activity of PI3K and the downstream kinase PDK1 are essential for the viability of two ABC DLBCL cell… CONTINUE READING
Highly Influential
This paper has highly influenced 10 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 49 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Essential role of MALT1 protease activity in activated B-cell– like diffuse large B-cell lymphoma

  • S Hailfinger
  • Proc Natl Acad Sci USA
  • 2009

The kinase PDK1 integrates T cell antigen receptor and CD28 coreceptor signaling to induce NF-kappaB and activate T cells

  • SG Park
  • Nat Immunol
  • 2009

Similar Papers

Loading similar papers…