Critical role of PD-1/PD-L1 pathway in generation and function of follicular regulatory T cells

@article{Hu2013CriticalRO,
  title={Critical role of PD-1/PD-L1 pathway in generation and function of follicular regulatory T cells},
  author={Z Q Hu and Wei-hua Zhao},
  journal={Cellular and Molecular Immunology},
  year={2013},
  volume={10},
  pages={286-288}
}
T he balance between follicular helper T cells (TFH cells) and follicular regulatory T (Treg) cells (TFR cells) is one of the key factors for the development of humoral immune responses. How the balance is regulated, however, is largely unknown. In a recent issue of Nature Immunology, Sage et al. revealed a critical role of the programmed death-1 (PD-1)/PD-L1 pathway in TFR cell generation and function, which provides a novel insight into the mechanisms how TFH and TFR cells regulate antibody… CONTINUE READING
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