Critical role of NF-κB in pancreatic cancer

@inproceedings{Prabhu2014CriticalRO,
  title={Critical role of NF-κB in pancreatic cancer},
  author={L. Arokia Jesu Prabhu and Rasika Mundade and Murray Korc and Patrick J. Loehrer and Tao Lu},
  booktitle={Oncotarget},
  year={2014}
}
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, and in spite of intense efforts there are limited therapeutic options for patients with PDAC. PDACs harbor a high frequency of Kras mutations and other driver mutations that lead to altered signaling pathways and contribute to therapeutic resistance. Importantly, constitutive activation of nuclear factor κB (NF-κB) is frequently observed in PDAC. An increasing body of evidence suggests that both classical and non-classical… CONTINUE READING

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