Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells.

@article{Hoshino2010CriticalRO,
  title={Critical role of IkappaB Kinase alpha in TLR7/9-induced type I IFN production by conventional dendritic cells.},
  author={Katsuaki Hoshino and Izumi Sasaki and Takahiro Sugiyama and Takahiro Yano and Chihiro Yamazaki and Teruhito Yasui and Hitoshi Kikutani and Tsuneyasu Kaisho},
  journal={Journal of immunology},
  year={2010},
  volume={184 7},
  pages={3341-5}
}
A plasmacytoid dendritic cell (DC) can produce large amounts of type I IFNs after sensing nucleic acids through TLR7 and TLR9. IkappaB kinase alpha (IKKalpha) is critically involved in this type I IFN production through its interaction with IFN regulatory factor-7. In response to TLR7/9 signaling, conventional DCs can also produce IFN-beta but not IFN-alpha in a type I IFN-independent manner. In this study, we showed that IKKalpha was required for production of IFN-beta, but not of… CONTINUE READING