Critical role of IL-17RA in immunopathology of influenza infection.

  title={Critical role of IL-17RA in immunopathology of influenza infection.},
  author={Christopher R. Crowe and Kong Chen and Derek A Pociask and John F Alcorn and Cameron Krivich and Richard I Enelow and Ted M Ross and Joseph L. Witztum and Jay K Kolls},
  journal={Journal of immunology},
  volume={183 8},
Acute lung injury due to influenza infection is associated with high mortality, an increase in neutrophils in the airspace, and increases in tissue myeloperoxidase (MPO). Because IL-17A and IL-17F, ligands for IL-17 receptor antagonist (IL-17RA), have been shown to mediate neutrophil migration into the lung in response to LPS or Gram-negative bacterial pneumonia, we hypothesized that IL-17RA signaling was critical for acute lung injury in response to pulmonary influenza infection. IL-17RA was… CONTINUE READING