Critical role of CD28 in protective immunity against Salmonella typhimurium.

  title={Critical role of CD28 in protective immunity against Salmonella typhimurium.},
  author={Hans-Willi Mittr{\"u}cker and Anne Koehler and Tak W Mak and Stefan H. E. Kaufmann},
  journal={Journal of immunology},
  volume={163 12},
Efficient T cell activation requires both TCR signals and costimulatory signals. CD28 is one of the molecules that provide costimulatory signals for T cells. We used mice deficient in CD28 expression (CD28-/- mice) to analyze the role of CD28 in the immune response against the intracellular bacterium Salmonella typhimurium, the causative agent of murine typhoid fever. CD28-/- mice were highly susceptible to infection with wild-type S. typhimurium and even failed to control infection with… CONTINUE READING

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