Critical role of β-hairpin formation in protein G folding

  title={Critical role of β-hairpin formation in protein G folding},
  author={Erika L. McCallister and Eric Alm and David Baker},
  journal={Nature Structural Biology},
Comparison of the folding mechanisms of proteins with similar structures but very different sequences can provide fundamental insights into the determinants of protein folding mechanisms. Despite very little sequence similarity, the ∼60 residue IgG binding domains of protein G and protein L both consist of a single helix packed against a four-stranded sheet formed by two symmetrically disposed β-hairpins. We demonstrate that, as in the case of protein L, one of the two β-turns of protein G is… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 32 extracted citations

Folding with a protein's native shortcut network.

Proteins • 2018
View 8 Excerpts
Highly Influenced

The origins of asymmetry in the folding transition states of protein L and protein G.

Protein science : a publication of the Protein Society • 2002
View 5 Excerpts
Highly Influenced


Publications referenced by this paper.

Nature America Inc. • © 2 00 0 N at u re A m er ic a In c

D.J.A. Bacon, W. F. Anderson
Mol. Graph • 1988

Similar Papers

Loading similar papers…