Critical role of β-hairpin formation in protein G folding

@article{McCallister2000CriticalRO,
  title={Critical role of β-hairpin formation in protein G folding},
  author={Erika L. McCallister and Eric Alm and David Baker},
  journal={Nature Structural Biology},
  year={2000},
  volume={7},
  pages={669-673}
}
Comparison of the folding mechanisms of proteins with similar structures but very different sequences can provide fundamental insights into the determinants of protein folding mechanisms. Despite very little sequence similarity, the ∼60 residue IgG binding domains of protein G and protein L both consist of a single helix packed against a four-stranded sheet formed by two symmetrically disposed β-hairpins. We demonstrate that, as in the case of protein L, one of the two β-turns of protein G is… CONTINUE READING

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