Critical role for the kinesin KIF3A in the HIV life cycle in primary human macrophages

@inproceedings{Gaudin2012CriticalRF,
  title={Critical role for the kinesin KIF3A in the HIV life cycle in primary human macrophages},
  author={Rapha{\"e}l Gaudin and Bruna Cunha de Alencar and M. Jouve and Stefano B{\`e}rre and Emmanuel Le Bouder and Michael Schindler and Aditi Varthaman and François-Xavier Gobert and Philippe Benaroch},
  booktitle={The Journal of cell biology},
  year={2012}
}
Macrophages are long-lived target cells for HIV infection and are considered viral reservoirs. HIV assembly in macrophages occurs in virus-containing compartments (VCCs) in which virions accumulate and are stored. The regulation of the trafficking and release of these VCCs remains unknown. Using high resolution light and electron microscopy of HIV-1-infected primary human macrophages, we show that the spatial distribution of VCCs depended on the microtubule network and that VCC-limiting… CONTINUE READING

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