Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome.

  title={Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome.},
  author={John A Belperio and Michael P. Keane and Marie D. Burdick and Joseph Pedulla Lynch and Ying Ying Xue and Aaron A. Berlin and David J. Ross and Steven L. Kunkel and Israel F. Charo and Robert M. Strieter},
  journal={The Journal of clinical investigation},
  volume={108 4},
Bronchiolitis obliterans syndrome (BOS) is the major limitation to survival after lung transplantation. Acute rejection, its main risk factor, is characterized by perivascular/bronchiolar leukocyte infiltration. BOS is characterized by persistent peribronchiolar leukocyte recruitment leading to airway fibrosis and obliteration. The specific mechanism(s) by which these leukocytes are recruited are unknown. Because MCP-1, acting through its receptor CCR2, is a potent mononuclear cell… CONTINUE READING
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