Critical role for stromal interaction molecule 1 in cardiac hypertrophy.

  title={Critical role for stromal interaction molecule 1 in cardiac hypertrophy.},
  author={Jean-S{\'e}bastien Hulot and J{\'e}r{\'e}my Fauconnier and Deepak Ramanujam and Antoine Chaanine and Fleur Cohen Aubart and Yassine Sassi and Sabine Merkle and Olivier Cazorla and Aude Ouill{\'e} and Morgan Dupuis and Lahouaria Hadri and Dongtak Jeong and Silke M{\"u}hlstedt and Joachim Schmitt and Attila Braun and Ludovic B{\'e}nard and Youakim Saliba and Bernhard Laggerbauer and Bernhard Nieswandt and Alain Lacampagne and Roger J. Hajjar and A. M. Lompr{\'e} and Stefan Engelhardt},
  volume={124 7},
BACKGROUND Cardiomyocytes use Ca2+ not only in excitation-contraction coupling but also as a signaling molecule promoting, for example, cardiac hypertrophy. It is largely unclear how Ca2+ triggers signaling in cardiomyocytes in the presence of the rapid and large Ca2+ fluctuations that occur during excitation-contraction coupling. A potential route is store-operated Ca2+ entry, a drug-inducible mechanism for Ca2+ signaling that requires stromal interaction molecule 1 (STIM1). Store-operated Ca2… CONTINUE READING
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