Critical role for peptide YY in protein-mediated satiation and body-weight regulation.

  title={Critical role for peptide YY in protein-mediated satiation and body-weight regulation.},
  author={R L Batterham and Helen Heffron and Saloni Kapoor and Joanna E. Chivers and Keval Chandarana and Herbert Herzog and Carel W le Roux and E. Louise Thomas and Jimmy D. Bell and Dominic J. Withers},
  journal={Cell metabolism},
  volume={4 3},
Dietary protein enhances satiety and promotes weight loss, but the mechanisms by which appetite is affected remain unclear. We investigated the role of gut hormones, key regulators of ingestive behavior, in mediating the satiating effects of different macronutrients. In normal-weight and obese human subjects, high-protein intake induced the greatest release of the anorectic hormone peptide YY (PYY) and the most pronounced satiety. Long-term augmentation of dietary protein in mice increased… CONTINUE READING
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