Critical role for osteopontin in diabetic nephropathy.

  title={Critical role for osteopontin in diabetic nephropathy.},
  author={Susanne B. Nicholas and Joey Liu and Jason D Kim and Yuelan Ren and Alan R. Collins and Lam Huu Nguyen and Willa A. Hsueh},
  journal={Kidney international},
  volume={77 7},
The profibrotic adhesion molecule, osteopontin (OPN), is upregulated in kidneys of humans and mice with diabetes. The thiazolidinedione (TZD) insulin sensitizers decrease albuminuria in diabetic nephropathy (DN) and reduce OPN expression in vascular and cardiac tissue. To examine whether OPN is a critical mediator of DN we treated db/db mice with insulin, rosiglitazone, or pioglitazone to achieve similar fasting plasma glucose levels. The urine albumin-to-creatinine ratio and glomerular OPN… CONTINUE READING


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