Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons.

@article{Gao2003CriticalRF,
  title={Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons.},
  author={Hui-ming Gao and Bin Liu and Jau-Shyong Hong},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 15},
  pages={
          6181-7
        }
}
Increasing evidence has suggested an important role for environmental toxins such as pesticides in the pathogenesis of Parkinson's disease (PD). Chronic exposure to rotenone, a common herbicide, reproduces features of Parkinsonism in rats. Mechanistically, rotenone-induced dopaminergic neurodegeneration has been associated with both its inhibition of neuronal mitochondrial complex I and the enhancement of activated microglia. Our previous studies with NADPH oxidase inhibitors, diphenylene… CONTINUE READING

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