Critical role for lysine 133 in the nuclear ubiquitin-mediated degradation of MyoD.

@article{Batonnet2004CriticalRF,
  title={Critical role for lysine 133 in the nuclear ubiquitin-mediated degradation of MyoD.},
  author={Sabrina Batonnet and Marie Pierre Leibovitch and Lionel A J Tintignac and Serge Alexandre Leibovitch},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 7},
  pages={5413-20}
}
The ubiquitin-proteasome system is responsible for the regulation and turnover of the nuclear transcription factor MyoD. The degradation of MyoD can occur via an NH2 terminus-dependent pathway or a lysine-dependent pathway, suggesting that MyoD ubiquitination may be driven by different mechanisms. To understand this process, deletion analysis was used to identify the region of MyoD that is required for rapid proteolysis in the lysine-dependent pathway. Here we report that the basic helix-loop… CONTINUE READING