Critical role for lipid raft-associated Src kinases in activation of PI3K-Akt signalling.

@article{Arcaro2007CriticalRF,
  title={Critical role for lipid raft-associated Src kinases in activation of PI3K-Akt signalling.},
  author={Alexandre Arcaro and Muriel Aubert and Maria E Espinosa del Hierro and Umme K. Khanzada and Smaragda Angelidou and Teresa D. Tetley and Anne Greet Bittermann and Margaret C Frame and Michael J. Seckl},
  journal={Cellular signalling},
  year={2007},
  volume={19 5},
  pages={
          1081-92
        }
}
Lipid rafts are membrane microdomains distinct from caveolae, whose functions in polypeptide growth factor signalling remain unclear. Here we show that in small cell lung cancer (SCLC) cells, specific growth factor receptors such as c-Kit associate with lipid rafts and that these domains play a critical role in the activation of phosphoinositide 3-kinase (PI3K) signalling. The class IA p85/p110alpha associated with Src in lipid rafts and was activated by Src in vitro. Lipid raft integrity was… CONTINUE READING
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