Critical role for heat shock protein 20 (HSP20) in migration of malarial sporozoites.

  title={Critical role for heat shock protein 20 (HSP20) in migration of malarial sporozoites.},
  author={Georgina N Montagna and Carlos A Buscaglia and Sylvia M{\"u}nter and Christian Goosmann and Friedrich Frischknecht and V Brinkmann and Kai Matuschewski},
  journal={The Journal of biological chemistry},
  volume={287 4},
Plasmodium sporozoites, single cell eukaryotic pathogens, use their own actin/myosin-based motor machinery for life cycle progression, which includes forward locomotion, penetration of cellular barriers, and invasion of target cells. To display fast gliding motility, the parasite uses a high turnover of actin polymerization and adhesion sites. Paradoxically, only a few classic actin regulatory proteins appear to be encoded in the Plasmodium genome. Small heat shock proteins have been associated… CONTINUE READING
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  • T. J. Jewett, L. D. Sibley
  • Mol. Cell 11,
  • 2003

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