Corpus ID: 44686979

Critical role for NF-kappaB-induced JunB in VEGF regulation and tumor angiogenesis.

@article{Schmidt2007CriticalRF,
  title={Critical role for NF-kappaB-induced JunB in VEGF regulation and tumor angiogenesis.},
  author={D. Schmidt and B. Textor and Oliver T. Pein and A. Licht and S. Andrecht and Melanie Sator-Schmitt and N. Fusenig and P. Angel and M. Schorpp-Kistner},
  journal={The EMBO journal},
  year={2007},
  volume={26 3},
  pages={
          710-9
        }
}
Regulation of vascular endothelial growth factor (VEGF) expression is a complex process involving a plethora of transcriptional regulators. The AP-1 transcription factor is considered as facilitator of hypoxia-induced VEGF expression through interaction with hypoxia-inducible factor (HIF) which plays a major role in mediating the cellular hypoxia response. As yet, both the decisive AP-1 subunit leading to VEGF induction and the molecular mechanism by which this subunit is activated have not… Expand
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