Critical role for Kalirin in nerve growth factor signaling through TrkA.

  title={Critical role for Kalirin in nerve growth factor signaling through TrkA.},
  author={Kausik Chakrabarti and Rong Lin and Noraisha I. Schiller and Yanping Wang and David Koubi and Ying-xin Fan and Brian B. Rudkin and Gibbes R. Johnson and Martin R. Schiller},
  journal={Molecular and cellular biology},
  volume={25 12},
Kalirin is a multidomain guanine nucleotide exchange factor (GEF) that activates Rho proteins, inducing cytoskeletal rearrangement in neurons. Although much is known about the effects of Kalirin on Rho GTPases and neuronal morphology, little is known about the association of Kalirin with the receptor/signaling systems that affect neuronal morphology. Our experiments demonstrate that Kalirin binds to and colocalizes with the TrkA neurotrophin receptor in neurons. In PC12 cells, inhibition of… CONTINUE READING


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