Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation.

@article{Franchi2007CriticalRF,
  title={Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation.},
  author={Luigi Franchi and Joshua S. Stoolman and Thirumala-Devi Kanneganti and Amrisha Verma and Reuben Ramphal and Gabriel N{\'u}{\~n}ez},
  journal={European journal of immunology},
  year={2007},
  volume={37 11},
  pages={
          3030-9
        }
}
Pseudomonas aeruginosa is an opportunistic Gram-negative human pathogen that is responsible for a broad range of infections in individuals with a variety of predisposing conditions. After infection, P. aeruginosa induces a marked inflammatory response in the host. However the mechanisms involved in bacterium recognition and induction of immune responses are poorly understood. Here we report that the Nod-like receptor family member Ipaf is required for optimal bacterial clearance in an in vivo… CONTINUE READING

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