• Medicine
  • Published in
    European journal of…
    2008

Critical role for IFN-gamma in natural killer cell-mediated protection from diabetes.

@article{Lee2008CriticalRF,
  title={Critical role for IFN-gamma in natural killer cell-mediated protection from diabetes.},
  author={I-Fang Lee and Huilian Qin and John J Priatel and Rusung Tan},
  journal={European journal of immunology},
  year={2008},
  volume={38 1},
  pages={
          82-9
        }
}
Autoimmune diabetes in nonobese diabetic (NOD) mice can be prevented by a single injection of complete Freund's adjuvant (CFA), but the mechanisms mediating protection remains unclear. We previously showed that NOD mice immunized with CFA have a markedly reduced incidence of diabetes that is associated with a significant decrease in the number of beta-cell-specific, autoreactive cytotoxic T lymphocytes and, furthermore, that the effect of CFA is mediated by natural killer (NK) cells. In this… CONTINUE READING

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