Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA.

@article{Kanneganti2006CriticalRF,
  title={Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA.},
  author={Thirumala-Devi Kanneganti and Mathilde Body-Malapel and Amal Bin Amer and Jong-Hwan Park and Joel R. Whitfield and Luigi Franchi and Zenobia F. Taraporewala and David Miller and John T Patton and Naohiro Inohara and Gabriel N{\'u}{\~n}ez},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 48},
  pages={36560-8}
}
Viral infection induces the production of interleukin (IL)-1beta and IL-18 in macrophages through the activation of caspase-1, but the mechanism by which host cells sense viruses to induce caspase-1 activation is unknown. In this report, we have identified a signaling pathway leading to caspase-1 activation that is induced by double-stranded RNA (dsRNA) and viral infection that is mediated by Cryopyrin/Nalp3. Stimulation of macrophages with dsRNA, viral RNA, or its analog poly(I:C) induced the… CONTINUE READING
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