Critical role for CXCR6 in NK cell-mediated antigen-specific memory to haptens and viruses

@inproceedings{Paust2010CriticalRF,
  title={Critical role for CXCR6 in NK cell-mediated antigen-specific memory to haptens and viruses},
  author={Silke Paust and Harvinder Singh Gill and Baozhong Wang and Michael P. Flynn and Elizabeth Moseman and Balimkiz Senman and Marian Szczepanik and Amalio Telenti and Philip W. Askenase and Richard W. Compans and Ulrich H von Andrian},
  booktitle={Nature Immunology},
  year={2010}
}
Hepatic natural killer (NK) cells mediate antigen-specific contact hypersensitivity (CHS) in mice deficient in T cells and B cells. We report here that hepatic NK cells, but not splenic or naive NK cells, also developed specific memory of vaccines containing antigens from influenza, vesicular stomatitis virus (VSV) or human immunodeficiency virus type 1 (HIV-1). Adoptive transfer of virus-sensitized NK cells into naive recipient mice enhanced the survival of the mice after lethal challenge with… CONTINUE READING
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