Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury.

@article{Belperio2002CriticalRF,
  title={Critical role for CXCR2 and CXCR2 ligands during the pathogenesis of ventilator-induced lung injury.},
  author={John A Belperio and Michael P. Keane and Marie D. Burdick and Vedang A. Londhe and Ying Ying Xue and Kewang Li and Roderick J. Phillips and Robert Strieter},
  journal={The Journal of clinical investigation},
  year={2002},
  volume={110 11},
  pages={
          1703-16
        }
}
Mortality related to adult respiratory distress syndrome (ARDS) ranges from 35% to 65%. Lung-protective ventilator strategies can reduce mortality during ARDS. The protective strategies limit tidal volumes and peak pressures while maximizing positive end-expiratory pressure. The efficacy of this approach is due to a reduction of shear-stress of the lung and release of inflammatory mediators. Ventilator-induced lung injury (VILI) is characterized by inflammation. The specific mechanism(s) that… 
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Neutrophil Extracellular Traps Are Pathogenic in Ventilator-Induced Lung Injury and Partially Dependent on TLR 4
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