Critical role for CXC chemokine ligand 16 (SR-PSOX) in Th1 response mediated by NKT cells.

  title={Critical role for CXC chemokine ligand 16 (SR-PSOX) in Th1 response mediated by NKT cells.},
  author={Takeshi Shimaoka and Ken-ichiro Seino and Noriaki Kume and Manabu Minami and Chiyoko Nishime and Makoto Suematsu and Toru Kita and Masaru Taniguchi and Kouji Matsushima and Shin Yonehara},
  journal={Journal of immunology},
  volume={179 12},
The transmembrane chemokine CXCL 16 (CXCL16), which is the same molecule as the scavenger receptor that binds phosphatidylserine and oxidized lipoprotein (SR-PSOX), has been shown to mediate chemotaxis and adhesion of CXC chemokine receptor 6-expressing cells such as NKT and activated Th1 cells. We generated SR-PSOX/CXCL16-deficient mice and examined the role of this chemokine in vivo. The mutant mice showed a reduced number of liver NKT cells, and decreased production of IFN-gamma and IL-4 by… CONTINUE READING


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