Critical review on the physical and mechanical factors involved in tissue engineering of cartilage.

  title={Critical review on the physical and mechanical factors involved in tissue engineering of cartilage.},
  author={Carrie Gaut and Kiminobu Sugaya},
  journal={Regenerative medicine},
  volume={10 5},
Articular cartilage defects often progress to osteoarthritis, which negatively impacts quality of life for millions of people worldwide and leads to high healthcare expenditures. Tissue engineering approaches to osteoarthritis have concentrated on proliferation and differentiation of stem cells by activation and suppression of signaling pathways, and by using a variety of scaffolding techniques. Recent studies indicate a key role of environmental factors in the differentiation of mesenchymal… 

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