Critical regulation of early Th17 cell differentiation by interleukin-1 signaling.

  title={Critical regulation of early Th17 cell differentiation by interleukin-1 signaling.},
  author={Yeonseok Chung and Seon Hee Chang and Gustavo J Martinez and Xuexian O. Yang and Roza Nurieva and Hong Soon Kang and Li Ma and Stephanie S Watowich and Anton M Jetten and Qiang Tian and Chen Dong},
  volume={30 4},
T helper (Th) 17 cells have been recently discovered in both mouse and human. Here we show that interleukin-1 (IL-1) signaling on T cells is critically required for the early programming of Th17 cell lineage and Th17 cell-mediated autoimmunity. IL-1 receptor1 expression in T cells, which was induced by IL-6, was necessary for the induction of experimental autoimmune encephalomyelitis and for early Th17 cell differentiation in vivo. Moreover, IL-1 signaling in T cells was required in dendritic… CONTINUE READING
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2008c). T helper 17 lineage differentiation is programmed by orphan nuclear receptors

  • X. O. Yang, B. P. Pappu, +8 authors K.S
  • ROR alpha and ROR gamma. Immunity
  • 2008
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TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing

  • L. Zhou, J. E. Lopes, +8 authors A.Y
  • RORgammat function
  • 2008
Highly Influential
12 Excerpts

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