Critical proliferation-independent window for basic fibroblast growth factor repression of myogenesis via the p42/p44 MAPK signaling pathway.

@article{Tortorella2001CriticalPW,
  title={Critical proliferation-independent window for basic fibroblast growth factor repression of myogenesis via the p42/p44 MAPK signaling pathway.},
  author={Lori L. Tortorella and Debra J. Milasincic and Paul F Pilch},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 17},
  pages={
          13709-17
        }
}
In many cell types including myoblasts, growth factors control proliferation and differentiation, in part, via the mitogen-activated protein kinase (MAPK) pathway (also known as the extracellular regulated kinase (Erk) pathway). In C2C12 myoblast cells, insulin-like growth factor-1 and basic fibroblast growth factor (bFGF) activate MAPK/Erk, and both growth factors promote myoblast proliferation. However, these factors have opposing roles with respect to differentiation; insulin-like growth… CONTINUE READING

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